Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2064282..2064928 Replicon chromosome
Accession NC_017154
Organism Yersinia pestis D106004

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag YPD4_RS09455 Protein ID WP_002214976.1
Coordinates 2064746..2064928 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag YPD4_RS09450 Protein ID WP_002211129.1
Coordinates 2064282..2064701 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPD4_RS09430 2059353..2060348 + 996 WP_002211125.1 substrate-binding domain-containing protein -
YPD4_RS09435 2060414..2061991 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
YPD4_RS09440 2061994..2063016 + 1023 WP_002214974.1 ABC transporter permease -
YPD4_RS09445 2063065..2064024 + 960 WP_002211128.1 sugar kinase -
YPD4_RS09450 2064282..2064701 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
YPD4_RS09455 2064746..2064928 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
YPD4_RS09460 2065135..2065917 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
YPD4_RS09465 2065920..2066189 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
YPD4_RS09470 2066295..2067035 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
YPD4_RS09475 2067116..2067652 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
YPD4_RS09480 2067652..2068068 - 417 WP_002211134.1 flagellar motor switch protein FliN -
YPD4_RS09485 2068065..2069066 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
YPD4_RS09490 2069072..2069542 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T26302 WP_002214976.1 NC_017154:c2064928-2064746 [Yersinia pestis D106004]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T26302 NC_017154:c2064928-2064746 [Yersinia pestis D106004]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT26302 WP_002211129.1 NC_017154:c2064701-2064282 [Yersinia pestis D106004]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT26302 NC_017154:c2064701-2064282 [Yersinia pestis D106004]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References