Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2808622..2809193 Replicon chromosome
Accession NZ_CP110069
Organism Enterococcus faecalis strain BE11

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OLL93_RS13630 Protein ID WP_002354774.1
Coordinates 2808622..2808963 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag OLL93_RS13635 Protein ID WP_002354773.1
Coordinates 2808963..2809193 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL93_RS13625 (2804637) 2804637..2808251 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
OLL93_RS13630 (2808622) 2808622..2808963 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OLL93_RS13635 (2808963) 2808963..2809193 - 231 WP_002354773.1 hypothetical protein Antitoxin
OLL93_RS13640 (2809599) 2809599..2809814 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
OLL93_RS13645 (2809953) 2809953..2810945 + 993 WP_002365428.1 biotin--[acetyl-CoA-carboxylase] ligase -
OLL93_RS13650 (2811012) 2811012..2811644 - 633 WP_002358972.1 RloB family protein -
OLL93_RS13655 (2811653) 2811653..2812948 - 1296 WP_002371641.1 ATP-binding protein -
OLL93_RS13660 (2812974) 2812974..2813108 - 135 WP_002391552.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T263016 WP_002354774.1 NZ_CP110069:c2808963-2808622 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT263016 WP_002354773.1 NZ_CP110069:c2809193-2808963 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References