263008

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2484835..2485625 Replicon chromosome
Accession NZ_CP110069
Organism Enterococcus faecalis strain BE11

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag OLL93_RS12105 Protein ID WP_033627270.1
Coordinates 2485236..2485625 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag OLL93_RS12100 Protein ID WP_002402312.1
Coordinates 2484835..2485221 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL93_RS12050 (2480531) 2480531..2481100 - 570 Protein_2344 cell division protein FtsK -
OLL93_RS12055 (2481188) 2481188..2481568 - 381 WP_002402315.1 DUF86 domain-containing protein -
OLL93_RS12060 (2481558) 2481558..2481884 - 327 WP_002394268.1 nucleotidyltransferase domain-containing protein -
OLL93_RS12065 (2481944) 2481944..2482237 - 294 WP_029655860.1 hypothetical protein -
OLL93_RS12070 (2482279) 2482279..2482431 - 153 WP_002371433.1 hypothetical protein -
OLL93_RS12075 (2482658) 2482658..2482846 + 189 WP_002371434.1 hypothetical protein -
OLL93_RS12080 (2482833) 2482833..2482994 - 162 WP_002380875.1 hypothetical protein -
OLL93_RS12085 (2483017) 2483017..2483433 - 417 WP_002380876.1 DUF961 family protein -
OLL93_RS12090 (2483433) 2483433..2483759 - 327 WP_002365226.1 hypothetical protein -
OLL93_RS12095 (2483845) 2483845..2484096 - 252 WP_010777935.1 hypothetical protein -
OLL93_RS12100 (2484835) 2484835..2485221 + 387 WP_002402312.1 helix-turn-helix transcriptional regulator Antitoxin
OLL93_RS12105 (2485236) 2485236..2485625 + 390 WP_033627270.1 hypothetical protein Toxin
OLL93_RS12110 (2485893) 2485893..2486228 + 336 WP_002402309.1 helix-turn-helix domain-containing protein -
OLL93_RS12115 (2486266) 2486266..2487597 - 1332 WP_002402308.1 FAD-dependent oxidoreductase -
OLL93_RS12120 (2487696) 2487696..2488571 - 876 WP_010785430.1 aldo/keto reductase -
OLL93_RS12125 (2488648) 2488648..2489067 - 420 WP_002380882.1 MerR family transcriptional regulator -
OLL93_RS12130 (2489084) 2489084..2489664 - 581 Protein_2360 phosphoglycerate mutase family protein -
OLL93_RS12135 (2489864) 2489864..2490213 + 350 Protein_2361 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2418995..2486111 67116


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15501.78 Da        Isoelectric Point: 5.0434

>T263008 WP_033627270.1 NZ_CP110069:2485236-2485625 [Enterococcus faecalis]
VDFISKELYFEAFNFSNELIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDEVIITTN
KELMLERKNFTKMHEVIHYYIDIPKINNATHTFSDILLKNGYLMEDFPK

Download         Length: 390 bp

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 15181.05 Da        Isoelectric Point: 4.7886

>AT263008 WP_002402312.1 NZ_CP110069:2484835-2485221 [Enterococcus faecalis]
VTIIKTNERLKQLRENKELTQKELADLLHMDRSVYNKIESGARPIRDNELIQFADFYNVSTDYLTNRTNNPIPPEEKTNV
GQNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKERNKKD

Download         Length: 387 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References