Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 388690..389272 Replicon chromosome
Accession NZ_CP110069
Organism Enterococcus faecalis strain BE11

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag OLL93_RS01975 Protein ID WP_002355414.1
Coordinates 388964..389272 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag OLL93_RS01970 Protein ID WP_002326825.1
Coordinates 388690..388962 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL93_RS01950 (383909) 383909..384310 - 402 WP_002364925.1 sigma-70 family RNA polymerase sigma factor -
OLL93_RS01960 (387533) 387533..388387 + 855 WP_002364921.1 ParA family protein -
OLL93_RS01965 (388458) 388458..388673 + 216 WP_002364919.1 peptide-binding protein -
OLL93_RS01970 (388690) 388690..388962 + 273 WP_002326825.1 antitoxin Antitoxin
OLL93_RS01975 (388964) 388964..389272 + 309 WP_002355414.1 zeta toxin family protein Toxin
OLL93_RS01980 (389352) 389352..389774 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
OLL93_RS01985 (389825) 389825..390325 - 501 WP_002355415.1 HAD family hydrolase -
OLL93_RS01990 (390330) 390330..391097 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
OLL93_RS01995 (391585) 391585..392010 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
OLL93_RS02000 (392027) 392027..392542 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
OLL93_RS02005 (392553) 392553..393485 + 933 WP_264522665.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T263004 WP_002355414.1 NZ_CP110069:388964-389272 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT263004 WP_002326825.1 NZ_CP110069:388690-388962 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References