262992

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2583453..2584138 Replicon chromosome
Accession NZ_CP110068
Organism Enterococcus faecalis strain BE13

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag OLM02_RS12720 Protein ID WP_016634626.1
Coordinates 2583794..2584138 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag OLM02_RS12715 Protein ID WP_010826721.1
Coordinates 2583453..2583776 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLM02_RS12670 (2578771) 2578771..2579550 - 780 WP_142959398.1 DnaD domain protein -
OLM02_RS12675 (2579565) 2579565..2580380 - 816 WP_002365125.1 PD-(D/E)XK nuclease-like domain-containing protein -
OLM02_RS12680 (2580343) 2580343..2581308 - 966 WP_010717378.1 RecT family recombinase -
OLM02_RS12685 (2581409) 2581409..2581633 - 225 WP_002367281.1 hypothetical protein -
OLM02_RS12690 (2581742) 2581742..2582158 - 417 WP_002370016.1 hypothetical protein -
OLM02_RS12695 (2582352) 2582352..2582495 - 144 WP_162837301.1 hypothetical protein -
OLM02_RS12700 (2582506) 2582506..2582682 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
OLM02_RS12705 (2582759) 2582759..2582968 + 210 WP_010731659.1 hypothetical protein -
OLM02_RS12710 (2582965) 2582965..2583147 - 183 WP_264522709.1 hypothetical protein -
OLM02_RS12715 (2583453) 2583453..2583776 + 324 WP_010826721.1 helix-turn-helix transcriptional regulator Antitoxin
OLM02_RS12720 (2583794) 2583794..2584138 + 345 WP_016634626.1 ImmA/IrrE family metallo-endopeptidase Toxin
OLM02_RS12725 (2584173) 2584173..2584901 + 729 WP_010826723.1 potassium channel family protein -
OLM02_RS12730 (2584996) 2584996..2586363 + 1368 WP_142959721.1 recombinase family protein -
OLM02_RS12735 (2586385) 2586385..2586960 - 576 WP_002393061.1 DNA repair protein RadC -
OLM02_RS12740 (2586992) 2586992..2587651 - 660 WP_002398690.1 HAD family hydrolase -
OLM02_RS12745 (2587635) 2587635..2588957 - 1323 WP_010821842.1 folylpolyglutamate synthase/dihydrofolate synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2544049..2586363 42314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-80)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13667.60 Da        Isoelectric Point: 6.2208

>T262992 WP_016634626.1 NZ_CP110068:2583794-2584138 [Enterococcus faecalis]
MKSIKELVEEYNVELVFAPINKRACYESVKRIIFVNQNLSIEEQEEAIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKNDGQFNYSNVITHYNLKMGQENYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12330.96 Da        Isoelectric Point: 5.2520

>AT262992 WP_010826721.1 NZ_CP110068:2583453-2583776 [Enterococcus faecalis]
MTVFDRVKKLADSQKISIVELEEKLNFSRNSLYAWKKSKPSIDKLEAVANYFGVSTDYLLGREISNKPKQSDDLDEILDN
VMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References