262989

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 426466..427048 Replicon chromosome
Accession NZ_CP110068
Organism Enterococcus faecalis strain BE13

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag OLM02_RS02190 Protein ID WP_002355414.1
Coordinates 426740..427048 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag OLM02_RS02185 Protein ID WP_002326825.1
Coordinates 426466..426738 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLM02_RS02160 (422208) 422208..422447 + 240 WP_250864631.1 DNA topoisomerase -
OLM02_RS02165 (422540) 422540..423823 + 1284 WP_010822049.1 type IA DNA topoisomerase -
OLM02_RS02175 (425309) 425309..426163 + 855 WP_010822050.1 ParA family protein -
OLM02_RS02180 (426234) 426234..426449 + 216 WP_002355411.1 peptide-binding protein -
OLM02_RS02185 (426466) 426466..426738 + 273 WP_002326825.1 antitoxin Antitoxin
OLM02_RS02190 (426740) 426740..427048 + 309 WP_002355414.1 zeta toxin family protein Toxin
OLM02_RS02195 (427128) 427128..427550 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
OLM02_RS02200 (427601) 427601..428101 - 501 WP_002355415.1 HAD family hydrolase -
OLM02_RS02205 (428106) 428106..428873 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
OLM02_RS02210 (429363) 429363..429788 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
OLM02_RS02215 (429805) 429805..430320 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
OLM02_RS02220 (430331) 430331..431263 + 933 WP_010822051.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T262989 WP_002355414.1 NZ_CP110068:426740-427048 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT262989 WP_002326825.1 NZ_CP110068:426466-426738 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References