Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 433213..433765 Replicon chromosome
Accession NZ_CP110063
Organism Enterococcus faecalis strain BE15

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag OLL96_RS02245 Protein ID WP_002355414.1
Coordinates 433457..433765 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID -
Locus tag OLL96_RS02240 Protein ID WP_034439854.1
Coordinates 433213..433455 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL96_RS02220 (428864) 428864..430540 + 1677 WP_010709001.1 type IA DNA topoisomerase -
OLL96_RS02230 (432026) 432026..432880 + 855 WP_002364921.1 ParA family protein -
OLL96_RS02235 (432951) 432951..433166 + 216 WP_002364919.1 peptide-binding protein -
OLL96_RS02240 (433213) 433213..433455 + 243 WP_034439854.1 antitoxin Antitoxin
OLL96_RS02245 (433457) 433457..433765 + 309 WP_002355414.1 zeta toxin family protein Toxin
OLL96_RS02250 (433845) 433845..434267 - 423 WP_229236149.1 tyrosine-type recombinase/integrase -
OLL96_RS02255 (434318) 434318..434818 - 501 WP_002355415.1 HAD family hydrolase -
OLL96_RS02260 (434823) 434823..435590 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
OLL96_RS02265 (436070) 436070..436495 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
OLL96_RS02270 (436512) 436512..437027 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
OLL96_RS02275 (437038) 437038..437970 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage ClpL - 376842..434818 57976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(1-80)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T262961 WP_002355414.1 NZ_CP110063:433457-433765 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9519.79 Da        Isoelectric Point: 4.5615

>AT262961 WP_034439854.1 NZ_CP110063:433213-433455 [Enterococcus faecalis]
IEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYSKQILTKEKVA

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure

References