262936

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 19465..20036 Replicon plasmid pBE17_1
Accession NZ_CP110055
Organism Enterococcus faecalis strain BE17

Toxin (Protein)


Gene name mazF Uniprot ID S4H3R9
Locus tag OLL95_RS13980 Protein ID WP_010784114.1
Coordinates 19695..20036 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3KHK9
Locus tag OLL95_RS13975 Protein ID WP_002362431.1
Coordinates 19465..19695 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL95_RS13940 (OLL95_13940) 15251..15907 + 657 WP_240185281.1 TraB/GumN family protein -
OLL95_RS13945 (OLL95_13945) 15936..16178 + 243 WP_240185280.1 hypothetical protein -
OLL95_RS13955 (OLL95_13955) 17801..17980 - 180 WP_104858764.1 transcriptional regulator -
OLL95_RS13960 (OLL95_13960) 18090..18353 - 264 WP_104858763.1 hypothetical protein -
OLL95_RS13965 (OLL95_13965) 18340..18651 - 312 WP_033628686.1 hypothetical protein -
OLL95_RS13970 (OLL95_13970) 18641..19261 - 621 WP_161971889.1 recombinase family protein -
OLL95_RS13975 (OLL95_13975) 19465..19695 + 231 WP_002362431.1 hypothetical protein Antitoxin
OLL95_RS13980 (OLL95_13980) 19695..20036 + 342 WP_010784114.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OLL95_RS13985 (OLL95_13985) 20148..20615 + 468 WP_264547814.1 hypothetical protein -
OLL95_RS13990 (OLL95_13990) 20668..21087 + 420 WP_264547815.1 hypothetical protein -
OLL95_RS13995 (OLL95_13995) 21352..21954 + 603 WP_002362434.1 Fic family protein -
OLL95_RS14000 (OLL95_14000) 22427..23386 - 960 WP_000221326.1 IS30-like element IS6770 family transposase -
OLL95_RS14005 (OLL95_14005) 23444..23857 + 414 WP_264547816.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..56232 56232
- inside IScluster/Tn - - 4790..23386 18596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13270.47 Da        Isoelectric Point: 7.9750

>T262936 WP_010784114.1 NZ_CP110055:19695-20036 [Enterococcus faecalis]
MSDEKKYIPKKGDIVWIDFDPSAEKEIQKRRPGLVVSRYEFNRKTLFAVICPITSTIKNMPTRYTLPDEMETHGQVVISQ
LKSLDFAERKLSQIEYLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8510.42 Da        Isoelectric Point: 4.3855

>AT262936 WP_002362431.1 NZ_CP110055:19465-19695 [Enterococcus faecalis]
MLTTKSRKQGSSVVLTLPSNNGQKPKADQEYIVMYSDDGTITLVPKLQDPFSGGSEGEYYEKDEWHDIEPGGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4H3R9

Antitoxin

Source ID Structure
AlphaFold DB R3KHK9

References