Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 1925774..1926740 Replicon chromosome
Accession NC_017154
Organism Yersinia pestis D106004

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag YPD4_RS08790 Protein ID WP_002210981.1
Coordinates 1925774..1926232 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag YPD4_RS08795 Protein ID WP_002210982.1
Coordinates 1926294..1926740 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPD4_RS08760 1921590..1922255 + 666 WP_002210975.1 phage shock protein PspA -
YPD4_RS08765 1922417..1922644 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
YPD4_RS08770 1922644..1923003 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
YPD4_RS08775 1923088..1923330 + 243 WP_002216375.1 phage shock protein PspD -
YPD4_RS08780 1923311..1924706 + 1396 Protein_1661 YcjX family protein -
YPD4_RS08785 1924703..1925764 + 1062 WP_002210980.1 YcjF family protein -
YPD4_RS08790 1925774..1926232 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
YPD4_RS08795 1926294..1926740 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
YPD4_RS08800 1927075..1928652 + 1578 WP_002210983.1 transcriptional regulator TyrR -
YPD4_RS08805 1928799..1929257 - 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
YPD4_RS08810 1929510..1930013 - 504 WP_002210984.1 thiol peroxidase -
YPD4_RS08815 1930264..1931046 - 783 WP_001317493.1 IS21-like element IS100kyp family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T26293 WP_002210981.1 NC_017154:c1926232-1925774 [Yersinia pestis D106004]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T26293 NC_017154:c1926232-1925774 [Yersinia pestis D106004]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT26293 WP_002210982.1 NC_017154:c1926740-1926294 [Yersinia pestis D106004]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT26293 NC_017154:c1926740-1926294 [Yersinia pestis D106004]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References