Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2657638..2658209 Replicon chromosome
Accession NZ_CP110053
Organism Enterococcus faecalis strain BE25

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag OLL87_RS12805 Protein ID WP_002360937.1
Coordinates 2657638..2657979 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag OLL87_RS12810 Protein ID WP_002354773.1
Coordinates 2657979..2658209 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL87_RS12800 (2653653) 2653653..2657267 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
OLL87_RS12805 (2657638) 2657638..2657979 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OLL87_RS12810 (2657979) 2657979..2658209 - 231 WP_002354773.1 hypothetical protein Antitoxin
OLL87_RS12815 (2658214) 2658214..2658417 - 204 WP_264547690.1 hypothetical protein -
OLL87_RS12820 (2658531) 2658531..2658746 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
OLL87_RS12825 (2658885) 2658885..2659877 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
OLL87_RS12830 (2659944) 2659944..2660576 - 633 WP_002358972.1 RloB family protein -
OLL87_RS12835 (2660585) 2660585..2661880 - 1296 WP_010820355.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T262910 WP_002360937.1 NZ_CP110053:c2657979-2657638 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT262910 WP_002354773.1 NZ_CP110053:c2658209-2657979 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References