Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2354276..2355312 Replicon chromosome
Accession NZ_CP110053
Organism Enterococcus faecalis strain BE25

Toxin (Protein)


Gene name IrrE Uniprot ID R3K9G6
Locus tag OLL87_RS11405 Protein ID WP_002365229.1
Coordinates 2354659..2355312 (+) Length 218 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag OLL87_RS11400 Protein ID WP_083578778.1
Coordinates 2354276..2354662 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL87_RS11360 (2350616) 2350616..2350996 - 381 WP_002402315.1 DUF86 domain-containing protein -
OLL87_RS11365 (2350986) 2350986..2351312 - 327 WP_002394268.1 nucleotidyltransferase domain-containing protein -
OLL87_RS11370 (2351372) 2351372..2351686 - 315 WP_002371431.1 hypothetical protein -
OLL87_RS11375 (2351706) 2351706..2351858 - 153 WP_002371433.1 hypothetical protein -
OLL87_RS11380 (2352085) 2352085..2352273 + 189 WP_002371434.1 hypothetical protein -
OLL87_RS11385 (2352461) 2352461..2352859 - 399 WP_002371435.1 DUF961 family protein -
OLL87_RS11390 (2352859) 2352859..2353185 - 327 WP_002371436.1 hypothetical protein -
OLL87_RS11395 (2353271) 2353271..2353522 - 252 WP_002365227.1 hypothetical protein -
OLL87_RS11400 (2354276) 2354276..2354662 + 387 WP_083578778.1 helix-turn-helix transcriptional regulator Antitoxin
OLL87_RS11405 (2354659) 2354659..2355312 + 654 WP_002365229.1 ImmA/IrrE family metallo-endopeptidase Toxin
OLL87_RS11410 (2355351) 2355351..2355686 + 336 WP_002365231.1 helix-turn-helix domain-containing protein -
OLL87_RS11415 (2355724) 2355724..2357055 - 1332 WP_002365232.1 FAD-dependent oxidoreductase -
OLL87_RS11420 (2357155) 2357155..2358030 - 876 WP_002380881.1 aldo/keto reductase -
OLL87_RS11425 (2358106) 2358106..2358525 - 420 WP_002380882.1 MerR family transcriptional regulator -
OLL87_RS11430 (2358542) 2358542..2359123 - 582 WP_002380883.1 histidine phosphatase family protein -
OLL87_RS11435 (2359345) 2359345..2359674 + 330 WP_083578777.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - EF3023 2338899..2588841 249942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(80-181)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 26065.01 Da        Isoelectric Point: 6.2394

>T262901 WP_002365229.1 NZ_CP110053:2354659-2355312 [Enterococcus faecalis]
MIGLLLVDFISKELYFEAFNFSNELIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDE
VIITTNKELMLERKNFTKMHEVMHYYIDIPKINNATHTFSDILLKNGYLMEDFPKEYRANVGASMLMANDQALFYALKKF
YSFEEIAQYFFMSKSALRNRLIEHLMYVNNCTFAHANTLFNNYYFHKETDIYRFIFN

Download         Length: 654 bp

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 15168.01 Da        Isoelectric Point: 4.9147

>AT262901 WP_083578778.1 NZ_CP110053:2354276-2354662 [Enterococcus faecalis]
VTIIKTNERLKQLRENKELTQKELADLLHMDRSVYNKIESGARPIRDNELIQFADFYNVSTDYLTNRTNNPTPPEEKTNV
GQNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKERNKKN

Download         Length: 387 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3K9G6

Antitoxin

Source ID Structure

References