Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 2440..2974 Replicon plasmid pCD1
Accession NC_017153
Organism Yersinia pestis D106004

Toxin (Protein)


Gene name parE Uniprot ID Q663N8
Locus tag YPD4_RS21430 Protein ID WP_002213360.1
Coordinates 2440..2739 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9ZGW3
Locus tag YPD4_RS21435 Protein ID WP_002224342.1
Coordinates 2732..2974 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPD4_RS21415 348..992 + 645 Protein_1 IS3 family transposase -
YPD4_RS21420 1055..1447 - 393 WP_002213403.1 type III secretion system chaperone SycE/YerA -
YPD4_RS21425 1641..2300 + 660 WP_002229754.1 type III secretion system effector GTPase activator YopE -
YPD4_RS21430 2440..2739 - 300 WP_002213360.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YPD4_RS21435 2732..2974 - 243 WP_002224342.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
YPD4_RS24320 3140..3432 - 293 Protein_6 IS6 family transposase -
YPD4_RS25265 3518..3691 + 174 WP_002213357.1 hypothetical protein -
YPD4_RS25070 3840..4076 - 237 WP_154020274.1 hypothetical protein -
YPD4_RS21445 4236..5201 - 966 WP_002213354.1 ParB/RepB/Spo0J family plasmid partition protein -
YPD4_RS21450 5198..6364 - 1167 WP_002220902.1 plasmid-partitioning protein SopA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - sycE/yerA / yopE / yopK/yopQ / yopT / sycT / yopM / yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscP / yscQ / yscR / yscS / yscT / yscU / virG/yscW / yscB / yscC / yscC / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / yopJ/yopP / yopO/ypkA / yadA / yadA / sycH 1..68342 68342
- flank IS/Tn - - 507..992 485


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

Antitoxin ParD

(5-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11632.19 Da        Isoelectric Point: 5.5114

>T26290 WP_002213360.1 NC_017153:c2739-2440 [Yersinia pestis D106004]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE

Download         Length: 300 bp

>T26290 NC_017153:c2739-2440 [Yersinia pestis D106004]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8865.15 Da        Isoelectric Point: 6.4781

>AT26290 WP_002224342.1 NC_017153:c2974-2732 [Yersinia pestis D106004]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV

Download         Length: 243 bp

>AT26290 NC_017153:c2974-2732 [Yersinia pestis D106004]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q663N8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NQY6

References