Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 2485021..2485811 | Replicon | chromosome |
| Accession | NZ_CP110050 | ||
| Organism | Enterococcus faecalis strain BE32 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | - |
| Locus tag | OLM04_RS12080 | Protein ID | WP_033627270.1 |
| Coordinates | 2485422..2485811 (+) | Length | 130 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | OLM04_RS12075 | Protein ID | WP_002402312.1 |
| Coordinates | 2485021..2485407 (+) | Length | 129 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OLM04_RS12025 (2480717) | 2480717..2481286 | - | 570 | Protein_2339 | cell division protein FtsK | - |
| OLM04_RS12030 (2481374) | 2481374..2481754 | - | 381 | WP_002402315.1 | DUF86 domain-containing protein | - |
| OLM04_RS12035 (2481744) | 2481744..2482070 | - | 327 | WP_002394268.1 | nucleotidyltransferase domain-containing protein | - |
| OLM04_RS12040 (2482130) | 2482130..2482423 | - | 294 | WP_029655860.1 | hypothetical protein | - |
| OLM04_RS12045 (2482465) | 2482465..2482617 | - | 153 | WP_002371433.1 | hypothetical protein | - |
| OLM04_RS12050 (2482844) | 2482844..2483032 | + | 189 | WP_002371434.1 | hypothetical protein | - |
| OLM04_RS12055 (2483019) | 2483019..2483180 | - | 162 | WP_002380875.1 | hypothetical protein | - |
| OLM04_RS12060 (2483203) | 2483203..2483619 | - | 417 | WP_002380876.1 | DUF961 family protein | - |
| OLM04_RS12065 (2483619) | 2483619..2483945 | - | 327 | WP_002365226.1 | hypothetical protein | - |
| OLM04_RS12070 (2484031) | 2484031..2484282 | - | 252 | WP_010777935.1 | hypothetical protein | - |
| OLM04_RS12075 (2485021) | 2485021..2485407 | + | 387 | WP_002402312.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| OLM04_RS12080 (2485422) | 2485422..2485811 | + | 390 | WP_033627270.1 | hypothetical protein | Toxin |
| OLM04_RS12085 (2486079) | 2486079..2486414 | + | 336 | WP_002402309.1 | helix-turn-helix domain-containing protein | - |
| OLM04_RS12090 (2486452) | 2486452..2487783 | - | 1332 | WP_002402308.1 | FAD-dependent oxidoreductase | - |
| OLM04_RS12095 (2487882) | 2487882..2488757 | - | 876 | WP_010785430.1 | aldo/keto reductase | - |
| OLM04_RS12100 (2488834) | 2488834..2489253 | - | 420 | WP_002380882.1 | MerR family transcriptional regulator | - |
| OLM04_RS12105 (2489270) | 2489270..2489850 | - | 581 | Protein_2355 | phosphoglycerate mutase family protein | - |
| OLM04_RS12110 (2490052) | 2490052..2490400 | + | 349 | Protein_2356 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2419181..2486297 | 67116 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 130 a.a. Molecular weight: 15501.78 Da Isoelectric Point: 5.0434
>T262880 WP_033627270.1 NZ_CP110050:2485422-2485811 [Enterococcus faecalis]
VDFISKELYFEAFNFSNELIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDEVIITTN
KELMLERKNFTKMHEVIHYYIDIPKINNATHTFSDILLKNGYLMEDFPK
VDFISKELYFEAFNFSNELIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDEVIITTN
KELMLERKNFTKMHEVIHYYIDIPKINNATHTFSDILLKNGYLMEDFPK
Download Length: 390 bp
>T262880 NZ_CP110050:2485422-2485811 [Enterococcus faecalis]
GTGGATTTTATTAGTAAAGAACTCTATTTTGAAGCATTTAATTTTTCGAACGAATTAATAAAAGAAGTATCATACTACTC
TTCCAAAAATATTGAACAAGTTAAATGCTTTGATATTGAAAAATATGTAAAAGAAGTTGAAGATGTTGAATTTGTTGAAT
ACACGTTTCAAAAACAACTTAAAAGACGGATGCTTGGTTCAATCTCTAAAGTAGACGATGAAGTCATTATAACAACAAAC
AAAGAATTAATGTTAGAACGAAAAAATTTCACTAAAATGCATGAGGTTATACATTACTACATAGATATACCTAAAATTAA
TAATGCAACTCATACTTTTTCTGATATTCTTTTAAAAAATGGTTACTTGATGGAAGATTTTCCAAAATAA
GTGGATTTTATTAGTAAAGAACTCTATTTTGAAGCATTTAATTTTTCGAACGAATTAATAAAAGAAGTATCATACTACTC
TTCCAAAAATATTGAACAAGTTAAATGCTTTGATATTGAAAAATATGTAAAAGAAGTTGAAGATGTTGAATTTGTTGAAT
ACACGTTTCAAAAACAACTTAAAAGACGGATGCTTGGTTCAATCTCTAAAGTAGACGATGAAGTCATTATAACAACAAAC
AAAGAATTAATGTTAGAACGAAAAAATTTCACTAAAATGCATGAGGTTATACATTACTACATAGATATACCTAAAATTAA
TAATGCAACTCATACTTTTTCTGATATTCTTTTAAAAAATGGTTACTTGATGGAAGATTTTCCAAAATAA
Antitoxin
Download Length: 129 a.a. Molecular weight: 15181.05 Da Isoelectric Point: 4.7886
>AT262880 WP_002402312.1 NZ_CP110050:2485021-2485407 [Enterococcus faecalis]
VTIIKTNERLKQLRENKELTQKELADLLHMDRSVYNKIESGARPIRDNELIQFADFYNVSTDYLTNRTNNPIPPEEKTNV
GQNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKERNKKD
VTIIKTNERLKQLRENKELTQKELADLLHMDRSVYNKIESGARPIRDNELIQFADFYNVSTDYLTNRTNNPIPPEEKTNV
GQNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKERNKKD
Download Length: 387 bp
>AT262880 NZ_CP110050:2485021-2485407 [Enterococcus faecalis]
GTGACTATTATTAAAACAAATGAACGTTTGAAACAACTACGTGAAAATAAAGAATTAACTCAAAAAGAATTAGCTGATTT
ACTACACATGGATAGAAGTGTTTATAATAAAATTGAATCAGGTGCTCGTCCCATTCGTGATAACGAACTAATTCAATTTG
CGGATTTCTATAATGTATCAACAGACTACCTTACAAATAGAACTAACAATCCCATTCCCCCTGAAGAAAAAACAAATGTG
GGACAAAATATCATCTCACATTTTCGTCTAAATACTTCTGATATGGACATAGAAGATATAGAAGAATTAGAAGAAGAATT
AATCGACTTTCAAGATTTTCTTATAAAAAAAGCAAAAGAAAAAAAGGAACGTAACAAAAAAGATTGA
GTGACTATTATTAAAACAAATGAACGTTTGAAACAACTACGTGAAAATAAAGAATTAACTCAAAAAGAATTAGCTGATTT
ACTACACATGGATAGAAGTGTTTATAATAAAATTGAATCAGGTGCTCGTCCCATTCGTGATAACGAACTAATTCAATTTG
CGGATTTCTATAATGTATCAACAGACTACCTTACAAATAGAACTAACAATCCCATTCCCCCTGAAGAAAAAACAAATGTG
GGACAAAATATCATCTCACATTTTCGTCTAAATACTTCTGATATGGACATAGAAGATATAGAAGAATTAGAAGAAGAATT
AATCGACTTTCAAGATTTTCTTATAAAAAAAGCAAAAGAAAAAAAGGAACGTAACAAAAAAGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|