262876

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 388688..389270 Replicon chromosome
Accession NZ_CP110050
Organism Enterococcus faecalis strain BE32

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag OLM04_RS01975 Protein ID WP_002355414.1
Coordinates 388962..389270 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag OLM04_RS01970 Protein ID WP_002326825.1
Coordinates 388688..388960 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLM04_RS01950 (383907) 383907..384308 - 402 WP_002364925.1 sigma-70 family RNA polymerase sigma factor -
OLM04_RS01960 (387531) 387531..388385 + 855 WP_002364921.1 ParA family protein -
OLM04_RS01965 (388456) 388456..388671 + 216 WP_002364919.1 peptide-binding protein -
OLM04_RS01970 (388688) 388688..388960 + 273 WP_002326825.1 antitoxin Antitoxin
OLM04_RS01975 (388962) 388962..389270 + 309 WP_002355414.1 zeta toxin family protein Toxin
OLM04_RS01980 (389350) 389350..389772 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
OLM04_RS01985 (389823) 389823..390323 - 501 WP_002355415.1 HAD family hydrolase -
OLM04_RS01990 (390328) 390328..391095 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
OLM04_RS01995 (391583) 391583..392008 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
OLM04_RS02000 (392025) 392025..392540 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
OLM04_RS02005 (392551) 392551..393483 + 933 WP_264522665.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T262876 WP_002355414.1 NZ_CP110050:388962-389270 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT262876 WP_002326825.1 NZ_CP110050:388688-388960 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References