262874

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 21332..21866 Replicon plasmid pBE33_1
Accession NZ_CP110048
Organism Enterococcus faecalis strain BE33

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag OLL90_RS14230 Protein ID WP_002360769.1
Coordinates 21591..21866 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag OLL90_RS14225 Protein ID WP_002369771.1
Coordinates 21332..21598 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL90_RS14185 (16953) 16953..17738 + 786 WP_002385543.1 replication-relaxation family protein -
OLL90_RS14190 (17744) 17744..18121 + 378 WP_010733799.1 hypothetical protein -
OLL90_RS14195 (18824) 18824..19090 + 267 WP_002365974.1 hypothetical protein -
OLL90_RS14200 (19123) 19123..19623 + 501 WP_002360775.1 DnaJ domain-containing protein -
OLL90_RS14205 (19636) 19636..19884 + 249 WP_002369776.1 DUF3850 domain-containing protein -
OLL90_RS14210 (19960) 19960..20376 + 417 WP_002368093.1 single-stranded DNA-binding protein -
OLL90_RS14215 (20400) 20400..20984 + 585 WP_010774883.1 thermonuclease family protein -
OLL90_RS14220 (20981) 20981..21229 + 249 WP_002369773.1 hypothetical protein -
OLL90_RS14225 (21332) 21332..21598 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OLL90_RS14230 (21591) 21591..21866 + 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
OLL90_RS14235 (22043) 22043..22234 + 192 WP_264541896.1 hypothetical protein -
OLL90_RS14240 (22650) 22650..22835 + 186 WP_002365983.1 hypothetical protein -
OLL90_RS14245 (22838) 22838..23011 + 174 WP_010774884.1 DpnD/PcfM family protein -
OLL90_RS14250 (23242) 23242..24021 + 780 WP_002365985.1 Cas9 inhibitor AcrIIA9 family protein -
OLL90_RS14255 (24021) 24021..25280 + 1260 WP_002365986.1 PcfJ domain-containing protein -
OLL90_RS14260 (25930) 25930..26658 + 729 WP_002383622.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43779 43779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-87)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T262874 WP_002360769.1 NZ_CP110048:21591-21866 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9804.15 Da        Isoelectric Point: 4.4791

>AT262874 WP_002369771.1 NZ_CP110048:21332-21598 [Enterococcus faecalis]
MATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References