262858

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2485096..2485886 Replicon chromosome
Accession NZ_CP110047
Organism Enterococcus faecalis strain BE33

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag OLL90_RS12100 Protein ID WP_033627270.1
Coordinates 2485497..2485886 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag OLL90_RS12095 Protein ID WP_002402312.1
Coordinates 2485096..2485482 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL90_RS12045 (2480792) 2480792..2481361 - 570 Protein_2343 cell division protein FtsK -
OLL90_RS12050 (2481449) 2481449..2481829 - 381 WP_002402315.1 DUF86 domain-containing protein -
OLL90_RS12055 (2481819) 2481819..2482145 - 327 WP_002394268.1 nucleotidyltransferase domain-containing protein -
OLL90_RS12060 (2482205) 2482205..2482498 - 294 WP_029655860.1 hypothetical protein -
OLL90_RS12065 (2482540) 2482540..2482692 - 153 WP_002371433.1 hypothetical protein -
OLL90_RS12070 (2482919) 2482919..2483107 + 189 WP_002371434.1 hypothetical protein -
OLL90_RS12075 (2483094) 2483094..2483255 - 162 WP_002380875.1 hypothetical protein -
OLL90_RS12080 (2483278) 2483278..2483694 - 417 WP_002380876.1 DUF961 family protein -
OLL90_RS12085 (2483694) 2483694..2484020 - 327 WP_002365226.1 hypothetical protein -
OLL90_RS12090 (2484106) 2484106..2484357 - 252 WP_010777935.1 hypothetical protein -
OLL90_RS12095 (2485096) 2485096..2485482 + 387 WP_002402312.1 helix-turn-helix transcriptional regulator Antitoxin
OLL90_RS12100 (2485497) 2485497..2485886 + 390 WP_033627270.1 hypothetical protein Toxin
OLL90_RS12105 (2486154) 2486154..2486489 + 336 WP_002402309.1 helix-turn-helix domain-containing protein -
OLL90_RS12110 (2486527) 2486527..2487858 - 1332 WP_002402308.1 FAD-dependent oxidoreductase -
OLL90_RS12115 (2487957) 2487957..2488832 - 876 WP_010785430.1 aldo/keto reductase -
OLL90_RS12120 (2488909) 2488909..2489328 - 420 WP_002380882.1 MerR family transcriptional regulator -
OLL90_RS12125 (2489345) 2489345..2489925 - 581 Protein_2359 phosphoglycerate mutase family protein -
OLL90_RS12130 (2490125) 2490125..2490474 + 350 Protein_2360 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2419254..2486372 67118


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15501.78 Da        Isoelectric Point: 5.0434

>T262858 WP_033627270.1 NZ_CP110047:2485497-2485886 [Enterococcus faecalis]
VDFISKELYFEAFNFSNELIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDEVIITTN
KELMLERKNFTKMHEVIHYYIDIPKINNATHTFSDILLKNGYLMEDFPK

Download         Length: 390 bp

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 15181.05 Da        Isoelectric Point: 4.7886

>AT262858 WP_002402312.1 NZ_CP110047:2485096-2485482 [Enterococcus faecalis]
VTIIKTNERLKQLRENKELTQKELADLLHMDRSVYNKIESGARPIRDNELIQFADFYNVSTDYLTNRTNNPIPPEEKTNV
GQNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKERNKKD

Download         Length: 387 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References