Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 21299..22436 Replicon plasmid pBE43_3
Accession NZ_CP110044
Organism Enterococcus faecalis strain BE43

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag OLM01_RS14810 Protein ID WP_264526513.1
Coordinates 21299..22162 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID -
Locus tag OLM01_RS14815 Protein ID WP_115253291.1
Coordinates 22164..22436 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLM01_RS14775 (OLM01_14775) 16469..16801 - 333 WP_000713503.1 CagC family type IV secretion system protein -
OLM01_RS14780 (OLM01_14780) 16825..18819 - 1995 WP_264526509.1 MobA/MobL family protein -
OLM01_RS14785 (OLM01_14785) 19102..19401 + 300 WP_264526510.1 hypothetical protein -
OLM01_RS14790 (OLM01_14790) 19404..19661 + 258 WP_264526511.1 hypothetical protein -
OLM01_RS14795 (OLM01_14795) 19684..19989 - 306 WP_264526512.1 hypothetical protein -
OLM01_RS14800 (OLM01_14800) 20023..20520 - 498 WP_002300565.1 molecular chaperone DnaJ -
OLM01_RS14805 (OLM01_14805) 20540..20857 - 318 WP_002338433.1 hypothetical protein -
OLM01_RS14810 (OLM01_14810) 21299..22162 - 864 WP_264526513.1 zeta toxin family protein Toxin
OLM01_RS14815 (OLM01_14815) 22164..22436 - 273 WP_115253291.1 antitoxin Antitoxin
OLM01_RS14820 (OLM01_14820) 22454..22669 - 216 WP_001835296.1 peptide-binding protein -
OLM01_RS14825 (OLM01_14825) 22761..23615 - 855 WP_264526514.1 ParA family protein -
OLM01_RS14830 (OLM01_14830) 23761..25905 - 2145 WP_264526515.1 type IA DNA topoisomerase -
OLM01_RS14835 (OLM01_14835) 25905..26522 - 618 WP_001062589.1 recombinase family protein -
OLM01_RS14840 (OLM01_14840) 26536..26706 - 171 WP_000713595.1 hypothetical protein -
OLM01_RS14845 (OLM01_14845) 26803..27147 - 345 WP_264526516.1 MerR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..28952 28952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(23-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32431.09 Da        Isoelectric Point: 6.9964

>T262852 WP_264526513.1 NZ_CP110044:c22162-21299 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELLQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYSLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMILNKHQETPEFKAIQQKLESLQPPTPPIPKIPKLPGI

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10719.27 Da        Isoelectric Point: 6.4676

>AT262852 WP_115253291.1 NZ_CP110044:c22436-22164 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAIHEYWRAMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References