262837

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2809861..2810432 Replicon chromosome
Accession NZ_CP110041
Organism Enterococcus faecalis strain BE43

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OLM01_RS13780 Protein ID WP_002354774.1
Coordinates 2809861..2810202 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag OLM01_RS13785 Protein ID WP_002354773.1
Coordinates 2810202..2810432 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLM01_RS13775 (2805876) 2805876..2809490 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
OLM01_RS13780 (2809861) 2809861..2810202 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OLM01_RS13785 (2810202) 2810202..2810432 - 231 WP_002354773.1 hypothetical protein Antitoxin
OLM01_RS13790 (2810763) 2810763..2810978 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
OLM01_RS13795 (2811117) 2811117..2812109 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
OLM01_RS13800 (2812373) 2812373..2813011 - 639 WP_073438309.1 lytic polysaccharide monooxygenase -
OLM01_RS13805 (2813697) 2813697..2815313 + 1617 WP_002406969.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T262837 WP_002354774.1 NZ_CP110041:c2810202-2809861 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT262837 WP_002354773.1 NZ_CP110041:c2810432-2810202 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References