Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2644529..2645100 Replicon chromosome
Accession NZ_CP110040
Organism Enterococcus faecalis strain BE45

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag OLM07_RS12955 Protein ID WP_002360937.1
Coordinates 2644529..2644870 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag OLM07_RS12960 Protein ID WP_002354773.1
Coordinates 2644870..2645100 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLM07_RS12950 (2640544) 2640544..2644158 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
OLM07_RS12955 (2644529) 2644529..2644870 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OLM07_RS12960 (2644870) 2644870..2645100 - 231 WP_002354773.1 hypothetical protein Antitoxin
OLM07_RS12965 (2645271) 2645271..2645486 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
OLM07_RS12970 (2645625) 2645625..2646617 + 993 WP_016630742.1 biotin--[acetyl-CoA-carboxylase] ligase -
OLM07_RS12975 (2646684) 2646684..2647316 - 633 WP_002358972.1 RloB family protein -
OLM07_RS12980 (2647325) 2647325..2648620 - 1296 WP_264547459.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T262821 WP_002360937.1 NZ_CP110040:c2644870-2644529 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT262821 WP_002354773.1 NZ_CP110040:c2645100-2644870 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References