262803

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 2356714..2357296 Replicon chromosome
Accession NZ_CP110036
Organism Enterococcus faecalis strain BE52

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag OLL99_RS11335 Protein ID WP_002355414.1
Coordinates 2356988..2357296 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag OLL99_RS11330 Protein ID WP_002326825.1
Coordinates 2356714..2356986 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL99_RS11310 (2352395) 2352395..2354071 + 1677 WP_010709001.1 type IA DNA topoisomerase -
OLL99_RS11320 (2355557) 2355557..2356411 + 855 WP_015212161.1 ParA family protein -
OLL99_RS11325 (2356482) 2356482..2356697 + 216 WP_002355411.1 peptide-binding protein -
OLL99_RS11330 (2356714) 2356714..2356986 + 273 WP_002326825.1 antitoxin Antitoxin
OLL99_RS11335 (2356988) 2356988..2357296 + 309 WP_002355414.1 zeta toxin family protein Toxin
OLL99_RS11340 (2357376) 2357376..2357798 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
OLL99_RS11345 (2357849) 2357849..2358349 - 501 WP_002355415.1 HAD family hydrolase -
OLL99_RS11350 (2358354) 2358354..2359121 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
OLL99_RS11355 (2359610) 2359610..2360035 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
OLL99_RS11360 (2360052) 2360052..2360567 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
OLL99_RS11365 (2360578) 2360578..2361510 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T262803 WP_002355414.1 NZ_CP110036:2356988-2357296 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT262803 WP_002326825.1 NZ_CP110036:2356714-2356986 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References