Detailed information of TA system TA026280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 157956..158541
• Replicon: plasmid pAPA12-014
• Accession: NC_017136
• Organism: Acetobacter pasteurianus IFO 3283-12

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: C7JIK9
• Locus tag: APA12_RS14385
• Protein ID: WP_012813213.1
• Coordinates: 157956..158285 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: C7JIL0
• Locus tag: APA12_RS14390
• Protein ID: WP_006115554.1
• Coordinates: 158287..158541 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APA12_RS16215	153773..153991	-	219	WP_170315285.1	WGR domain-containing protein	-
APA12_RS14345	154070..154348	-	279	WP_006115563.1	HU family DNA-binding protein	-
APA12_RS16680	155790..155975	-	186	WP_041633309.1	hypothetical protein	-
APA12_RS14365	156060..156875	+	816	WP_012813210.1	hypothetical protein	-
APA12_RS14370	156888..157292	+	405	WP_006115557.1	hypothetical protein	-
APA12_RS14375	157349..157669	-	321	WP_012813211.1	hypothetical protein	-
APA12_RS14380	157699..157899	-	201	WP_012813212.1	hypothetical protein	-
APA12_RS14385	157956..158285	-	330	WP_012813213.1	endoribonuclease MazF	Toxin
APA12_RS14390	158287..158541	-	255	WP_006115554.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
APA12_RS14395	158640..158948	-	309	WP_006115553.1	PIN domain-containing protein	-
APA12_RS14400	158945..159217	-	273	WP_006115552.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
APA12_RS14405	159547..159918	-	372	Protein_154	integrase core domain-containing protein	-
APA12_RS14410	160012..161397	+	1386	WP_012813126.1	IS1380-like element IS1380A family transposase	-
APA12_RS16230	161529..161980	+	452	Protein_156	recombinase family protein	-
APA12_RS14415	162294..163067	-	774	WP_003631418.1	TSUP family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..191411	191411

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (10-110)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 16207.44 Da
• Isoelectric Point: 5.5500

>T26280 WP_012813213.1 NC_017136:c158285-157956 [Acetobacter pasteurianus IFO 3283-12]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 330 bp

>T26280 NC_017136:c158285-157956 [Acetobacter pasteurianus IFO 3283-12]
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Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 12528.03 Da
• Isoelectric Point: 5.5500

>AT26280 WP_006115554.1 NC_017136:c158541-158287 [Acetobacter pasteurianus IFO 3283-12]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFF

Nucleotide

• Length: 255 bp

>AT26280 NC_017136:c158541-158287 [Acetobacter pasteurianus IFO 3283-12]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Structures

Toxin

• AlphaFold DB: A0A6P1QFJ7

Antitoxin

• AlphaFold DB: A0A6P1QDC4