262775

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 610303..611339 Replicon chromosome
Accession NZ_CP110020
Organism Enterococcus faecalis strain BE69

Toxin (Protein)


Gene name IrrE Uniprot ID R3K9G6
Locus tag OLM05_RS02905 Protein ID WP_002365229.1
Coordinates 610303..610956 (-) Length 218 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag OLM05_RS02910 Protein ID WP_002402312.1
Coordinates 610953..611339 (-) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLM05_RS02875 (605943) 605943..606272 - 330 WP_010715435.1 helix-turn-helix domain-containing protein -
OLM05_RS02880 (606494) 606494..607075 + 582 WP_002380883.1 histidine phosphatase family protein -
OLM05_RS02885 (607092) 607092..607511 + 420 WP_010715434.1 MerR family transcriptional regulator -
OLM05_RS02890 (607526) 607526..608461 + 936 WP_181039472.1 aldo/keto reductase -
OLM05_RS02895 (608560) 608560..609891 + 1332 WP_002380880.1 FAD-dependent oxidoreductase -
OLM05_RS02900 (609929) 609929..610264 - 336 WP_002365231.1 helix-turn-helix domain-containing protein -
OLM05_RS02905 (610303) 610303..610956 - 654 WP_002365229.1 ImmA/IrrE family metallo-endopeptidase Toxin
OLM05_RS02910 (610953) 610953..611339 - 387 WP_002402312.1 helix-turn-helix transcriptional regulator Antitoxin
OLM05_RS02915 (612093) 612093..612344 + 252 WP_002365227.1 hypothetical protein -
OLM05_RS02920 (612430) 612430..612756 + 327 WP_010715432.1 hypothetical protein -
OLM05_RS02925 (612756) 612756..613172 + 417 WP_002380876.1 DUF961 family protein -
OLM05_RS02930 (613195) 613195..613356 + 162 WP_002394272.1 hypothetical protein -
OLM05_RS02935 (613343) 613343..613531 - 189 WP_002394271.1 hypothetical protein -
OLM05_RS02940 (613758) 613758..613910 + 153 WP_002410057.1 hypothetical protein -
OLM05_RS02945 (613951) 613951..614244 + 294 WP_264516862.1 hypothetical protein -
OLM05_RS02950 (614304) 614304..614630 + 327 WP_010715430.1 nucleotidyltransferase domain-containing protein -
OLM05_RS02955 (614620) 614620..615000 + 381 WP_002394266.1 DUF86 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 592930..651061 58131


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(80-181)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 26065.01 Da        Isoelectric Point: 6.2394

>T262775 WP_002365229.1 NZ_CP110020:c610956-610303 [Enterococcus faecalis]
MIGLLLVDFISKELYFEAFNFSNELIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDE
VIITTNKELMLERKNFTKMHEVMHYYIDIPKINNATHTFSDILLKNGYLMEDFPKEYRANVGASMLMANDQALFYALKKF
YSFEEIAQYFFMSKSALRNRLIEHLMYVNNCTFAHANTLFNNYYFHKETDIYRFIFN

Download         Length: 654 bp

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 15181.05 Da        Isoelectric Point: 4.7886

>AT262775 WP_002402312.1 NZ_CP110020:c611339-610953 [Enterococcus faecalis]
VTIIKTNERLKQLRENKELTQKELADLLHMDRSVYNKIESGARPIRDNELIQFADFYNVSTDYLTNRTNNPIPPEEKTNV
GQNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKERNKKD

Download         Length: 387 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3K9G6

Antitoxin

Source ID Structure

References