262753

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2868251..2868918 Replicon chromosome
Accession NZ_CP110018
Organism Escherichia coli strain DH10B

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag OLR78_RS14175 Protein ID WP_001094400.1
Coordinates 2868589..2868918 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag OLR78_RS14170 Protein ID WP_000072690.1
Coordinates 2868251..2868568 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR78_RS14135 (2863303) 2863303..2864312 - 1010 Protein_2764 arsenic transporter -
OLR78_RS14140 (2864454) 2864454..2866157 + 1704 WP_000896263.1 protein YfjW -
OLR78_RS14145 (2866768) 2866768..2866952 + 185 Protein_2766 DUF905 family protein -
OLR78_RS14150 (2866920) 2866920..2867042 - 123 WP_001407482.1 hypothetical protein -
OLR78_RS14155 (2867055) 2867055..2867513 + 459 WP_000211841.1 antirestriction protein -
OLR78_RS14160 (2867522) 2867522..2868004 + 483 WP_001407480.1 RadC family protein -
OLR78_RS14165 (2868013) 2868013..2868213 + 201 WP_001395452.1 DUF987 domain-containing protein -
OLR78_RS14170 (2868251) 2868251..2868568 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OLR78_RS14175 (2868589) 2868589..2868918 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
OLR78_RS14180 (2869282) 2869282..2873862 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T262753 WP_001094400.1 NZ_CP110018:2868589-2868918 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT262753 WP_000072690.1 NZ_CP110018:2868251-2868568 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References