Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 418645..419263 Replicon chromosome
Accession NZ_CP110018
Organism Escherichia coli strain DH10B

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag OLR78_RS02100 Protein ID WP_001290581.1
Coordinates 418645..418863 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OLR78_RS02105 Protein ID WP_000344800.1
Coordinates 418889..419263 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR78_RS02065 (413934) 413934..414506 + 573 WP_000779842.1 YbaY family lipoprotein -
OLR78_RS02070 (414537) 414537..414848 - 312 WP_000409911.1 MGMT family protein -
OLR78_RS02080 (415227) 415227..415580 + 354 WP_000878140.1 DUF1428 domain-containing protein -
OLR78_RS02085 (415622) 415622..417172 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OLR78_RS02090 (417336) 417336..417806 - 471 WP_000136192.1 YlaC family protein -
OLR78_RS02095 (417922) 417922..418473 - 552 WP_000102564.1 maltose O-acetyltransferase -
OLR78_RS02100 (418645) 418645..418863 - 219 WP_001290581.1 HHA domain-containing protein Toxin
OLR78_RS02105 (418889) 418889..419263 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OLR78_RS02110 (419809) 419809..422958 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
OLR78_RS02115 (422981) 422981..424174 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8678.06 Da        Isoelectric Point: 8.9008

>T262739 WP_001290581.1 NZ_CP110018:c418863-418645 [Escherichia coli]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT262739 WP_000344800.1 NZ_CP110018:c419263-418889 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References