Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4548946..4549541 Replicon chromosome
Accession NZ_CP110017
Organism Escherichia coli strain HE_50

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag OLR76_RS22260 Protein ID WP_000239577.1
Coordinates 4549191..4549541 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag OLR76_RS22255 Protein ID WP_001223208.1
Coordinates 4548946..4549197 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR76_RS22245 (4544611) 4544611..4548390 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
OLR76_RS22250 (4548393) 4548393..4548734 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
OLR76_RS22255 (4548946) 4548946..4549197 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
OLR76_RS22260 (4549191) 4549191..4549541 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
OLR76_RS22265 (4549621) 4549621..4550151 - 531 WP_000055075.1 inorganic diphosphatase -
OLR76_RS22270 (4550461) 4550461..4551417 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
OLR76_RS22275 (4551557) 4551557..4553059 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
OLR76_RS22280 (4553073) 4553073..4553204 + 132 Protein_4337 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T262734 WP_000239577.1 NZ_CP110017:4549191-4549541 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT262734 WP_001223208.1 NZ_CP110017:4548946-4549197 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References