Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3133652..3134306 Replicon chromosome
Accession NZ_CP110017
Organism Escherichia coli strain HE_50

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag OLR76_RS15420 Protein ID WP_000244777.1
Coordinates 3133652..3134059 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag OLR76_RS15425 Protein ID WP_000354046.1
Coordinates 3134040..3134306 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR76_RS15400 (3129609) 3129609..3131342 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
OLR76_RS15405 (3131348) 3131348..3132058 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OLR76_RS15410 (3132083) 3132083..3132979 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OLR76_RS15415 (3133091) 3133091..3133612 + 522 WP_001055874.1 flavodoxin FldB -
OLR76_RS15420 (3133652) 3133652..3134059 - 408 WP_000244777.1 protein YgfX Toxin
OLR76_RS15425 (3134040) 3134040..3134306 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
OLR76_RS15430 (3134549) 3134549..3135529 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
OLR76_RS15435 (3135725) 3135725..3136384 - 660 WP_000250274.1 hemolysin III family protein -
OLR76_RS15440 (3136548) 3136548..3136859 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
OLR76_RS15445 (3136904) 3136904..3138337 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
OLR76_RS15450 (3138394) 3138394..3139137 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T262729 WP_000244777.1 NZ_CP110017:c3134059-3133652 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT262729 WP_000354046.1 NZ_CP110017:c3134306-3134040 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References