Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1597896..1598534 Replicon chromosome
Accession NZ_CP110017
Organism Escherichia coli strain HE_50

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OLR76_RS07935 Protein ID WP_000813794.1
Coordinates 1597896..1598072 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OLR76_RS07940 Protein ID WP_001270286.1
Coordinates 1598118..1598534 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR76_RS07915 (1593515) 1593515..1594729 - 1215 WP_001326689.1 BenE family transporter YdcO -
OLR76_RS07920 (1594782) 1594782..1595318 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
OLR76_RS07925 (1595391) 1595391..1597352 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OLR76_RS07930 (1597444) 1597444..1597674 - 231 WP_000494244.1 YncJ family protein -
OLR76_RS07935 (1597896) 1597896..1598072 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OLR76_RS07940 (1598118) 1598118..1598534 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OLR76_RS07945 (1598613) 1598613..1600019 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
OLR76_RS07950 (1600264) 1600264..1601409 + 1146 WP_282983529.1 ABC transporter substrate-binding protein -
OLR76_RS07955 (1601427) 1601427..1602440 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
OLR76_RS07960 (1602441) 1602441..1603382 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T262717 WP_000813794.1 NZ_CP110017:1597896-1598072 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT262717 WP_001270286.1 NZ_CP110017:1598118-1598534 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References