Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 418646..419264 Replicon chromosome
Accession NZ_CP110017
Organism Escherichia coli strain HE_50

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag OLR76_RS02100 Protein ID WP_001290581.1
Coordinates 418646..418864 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OLR76_RS02105 Protein ID WP_000344800.1
Coordinates 418890..419264 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR76_RS02065 (413935) 413935..414507 + 573 WP_000779842.1 YbaY family lipoprotein -
OLR76_RS02070 (414538) 414538..414849 - 312 WP_000409911.1 MGMT family protein -
OLR76_RS02080 (415228) 415228..415581 + 354 WP_000878140.1 DUF1428 domain-containing protein -
OLR76_RS02085 (415623) 415623..417173 - 1551 WP_282983422.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OLR76_RS02090 (417337) 417337..417807 - 471 WP_000136192.1 YlaC family protein -
OLR76_RS02095 (417923) 417923..418474 - 552 WP_000102564.1 maltose O-acetyltransferase -
OLR76_RS02100 (418646) 418646..418864 - 219 WP_001290581.1 HHA domain-containing protein Toxin
OLR76_RS02105 (418890) 418890..419264 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OLR76_RS02110 (419810) 419810..422959 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
OLR76_RS02115 (422982) 422982..424175 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8678.06 Da        Isoelectric Point: 8.9008

>T262713 WP_001290581.1 NZ_CP110017:c418864-418646 [Escherichia coli]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT262713 WP_000344800.1 NZ_CP110017:c419264-418890 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References