Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4548940..4549535 Replicon chromosome
Accession NZ_CP110016
Organism Escherichia coli strain HE_100

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag OLR74_RS22270 Protein ID WP_000239577.1
Coordinates 4549185..4549535 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag OLR74_RS22265 Protein ID WP_001223208.1
Coordinates 4548940..4549191 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR74_RS22255 (4544605) 4544605..4548384 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
OLR74_RS22260 (4548387) 4548387..4548728 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
OLR74_RS22265 (4548940) 4548940..4549191 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
OLR74_RS22270 (4549185) 4549185..4549535 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
OLR74_RS22275 (4549615) 4549615..4550145 - 531 WP_000055075.1 inorganic diphosphatase -
OLR74_RS22280 (4550455) 4550455..4551411 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
OLR74_RS22285 (4551551) 4551551..4553053 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
OLR74_RS22290 (4553067) 4553067..4553198 + 132 Protein_4339 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T262708 WP_000239577.1 NZ_CP110016:4549185-4549535 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT262708 WP_001223208.1 NZ_CP110016:4548940-4549191 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References