Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3133650..3134304 Replicon chromosome
Accession NZ_CP110016
Organism Escherichia coli strain HE_100

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag OLR74_RS15430 Protein ID WP_000244777.1
Coordinates 3133650..3134057 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag OLR74_RS15435 Protein ID WP_000354046.1
Coordinates 3134038..3134304 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR74_RS15410 (3129607) 3129607..3131340 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
OLR74_RS15415 (3131346) 3131346..3132056 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OLR74_RS15420 (3132081) 3132081..3132977 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OLR74_RS15425 (3133089) 3133089..3133610 + 522 WP_001055874.1 flavodoxin FldB -
OLR74_RS15430 (3133650) 3133650..3134057 - 408 WP_000244777.1 protein YgfX Toxin
OLR74_RS15435 (3134038) 3134038..3134304 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
OLR74_RS15440 (3134547) 3134547..3135527 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
OLR74_RS15445 (3135723) 3135723..3136382 - 660 WP_000250274.1 hemolysin III family protein -
OLR74_RS15450 (3136546) 3136546..3136857 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
OLR74_RS15455 (3136902) 3136902..3138335 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
OLR74_RS15460 (3138392) 3138392..3139135 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T262703 WP_000244777.1 NZ_CP110016:c3134057-3133650 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT262703 WP_000354046.1 NZ_CP110016:c3134304-3134038 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References