Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1597897..1598535 Replicon chromosome
Accession NZ_CP110016
Organism Escherichia coli strain HE_100

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OLR74_RS07945 Protein ID WP_000813794.1
Coordinates 1597897..1598073 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OLR74_RS07950 Protein ID WP_001270286.1
Coordinates 1598119..1598535 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR74_RS07925 (1593516) 1593516..1594730 - 1215 WP_001326689.1 BenE family transporter YdcO -
OLR74_RS07930 (1594783) 1594783..1595319 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
OLR74_RS07935 (1595392) 1595392..1597353 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OLR74_RS07940 (1597445) 1597445..1597675 - 231 WP_000494244.1 YncJ family protein -
OLR74_RS07945 (1597897) 1597897..1598073 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OLR74_RS07950 (1598119) 1598119..1598535 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OLR74_RS07955 (1598614) 1598614..1600020 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
OLR74_RS07960 (1600265) 1600265..1601410 + 1146 WP_282983529.1 ABC transporter substrate-binding protein -
OLR74_RS07965 (1601428) 1601428..1602441 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
OLR74_RS07970 (1602442) 1602442..1603383 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T262691 WP_000813794.1 NZ_CP110016:1597897-1598073 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT262691 WP_001270286.1 NZ_CP110016:1598119-1598535 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References