Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2868242..2868909 Replicon chromosome
Accession NZ_CP110015
Organism Escherichia coli strain HE_150

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag OLR73_RS14170 Protein ID WP_001094400.1
Coordinates 2868580..2868909 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag OLR73_RS14165 Protein ID WP_000072690.1
Coordinates 2868242..2868559 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR73_RS14130 (2863294) 2863294..2864303 - 1010 Protein_2763 arsenic transporter -
OLR73_RS14135 (2864445) 2864445..2866148 + 1704 WP_000896263.1 protein YfjW -
OLR73_RS14140 (2866759) 2866759..2866943 + 185 Protein_2765 DUF905 family protein -
OLR73_RS14145 (2866911) 2866911..2867033 - 123 WP_001407482.1 hypothetical protein -
OLR73_RS14150 (2867046) 2867046..2867504 + 459 WP_000211841.1 antirestriction protein -
OLR73_RS14155 (2867513) 2867513..2867995 + 483 WP_001407480.1 RadC family protein -
OLR73_RS14160 (2868004) 2868004..2868204 + 201 WP_001395452.1 DUF987 domain-containing protein -
OLR73_RS14165 (2868242) 2868242..2868559 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OLR73_RS14170 (2868580) 2868580..2868909 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
OLR73_RS14175 (2869273) 2869273..2873852 - 4580 Protein_2772 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T262675 WP_001094400.1 NZ_CP110015:2868580-2868909 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT262675 WP_000072690.1 NZ_CP110015:2868242-2868559 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References