Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1597895..1598533 Replicon chromosome
Accession NZ_CP110015
Organism Escherichia coli strain HE_150

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OLR73_RS07930 Protein ID WP_000813794.1
Coordinates 1597895..1598071 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OLR73_RS07935 Protein ID WP_001270286.1
Coordinates 1598117..1598533 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR73_RS07910 (1593514) 1593514..1594728 - 1215 WP_001326689.1 BenE family transporter YdcO -
OLR73_RS07915 (1594781) 1594781..1595317 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
OLR73_RS07920 (1595390) 1595390..1597351 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OLR73_RS07925 (1597443) 1597443..1597673 - 231 WP_000494244.1 YncJ family protein -
OLR73_RS07930 (1597895) 1597895..1598071 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OLR73_RS07935 (1598117) 1598117..1598533 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OLR73_RS07940 (1598612) 1598612..1600018 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
OLR73_RS07945 (1600263) 1600263..1601408 + 1146 WP_282983529.1 ABC transporter substrate-binding protein -
OLR73_RS07950 (1601426) 1601426..1602439 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
OLR73_RS07955 (1602440) 1602440..1603382 + 943 Protein_1553 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T262665 WP_000813794.1 NZ_CP110015:1597895-1598071 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT262665 WP_001270286.1 NZ_CP110015:1598117-1598533 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References