262656

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4548933..4549528 Replicon chromosome
Accession NZ_CP110014
Organism Escherichia coli strain HE_100-10

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag OLR77_RS22265 Protein ID WP_000239577.1
Coordinates 4549178..4549528 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag OLR77_RS22260 Protein ID WP_001223208.1
Coordinates 4548933..4549184 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR77_RS22250 (4544598) 4544598..4548377 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
OLR77_RS22255 (4548380) 4548380..4548721 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
OLR77_RS22260 (4548933) 4548933..4549184 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
OLR77_RS22265 (4549178) 4549178..4549528 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
OLR77_RS22270 (4549608) 4549608..4550138 - 531 WP_000055075.1 inorganic diphosphatase -
OLR77_RS22275 (4550448) 4550448..4551404 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
OLR77_RS22280 (4551544) 4551544..4553046 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
OLR77_RS22285 (4553060) 4553060..4553191 + 132 Protein_4338 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T262656 WP_000239577.1 NZ_CP110014:4549178-4549528 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT262656 WP_001223208.1 NZ_CP110014:4548933-4549184 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References