262655

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4453071..4453568 Replicon chromosome
Accession NZ_CP110014
Organism Escherichia coli strain HE_100-10

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag OLR77_RS21770 Protein ID WP_001173343.1
Coordinates 4453395..4453568 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag OLR77_RS21765 Protein ID WP_000398619.1
Coordinates 4453071..4453367 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR77_RS21745 (4449802) 4449802..4450521 - 720 WP_000611288.1 two-component system response regulator DcuR -
OLR77_RS21750 (4450518) 4450518..4452149 - 1632 WP_001216477.1 sensor histidine kinase -
OLR77_RS21755 (4452330) 4452330..4452560 + 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
OLR77_RS21760 (4452572) 4452572..4452844 + 273 WP_000405651.1 GNAT family N-acetyltransferase -
OLR77_RS21765 (4453071) 4453071..4453367 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
OLR77_RS21770 (4453395) 4453395..4453568 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
OLR77_RS21775 (4453687) 4453687..4455204 - 1518 WP_001295074.1 lysine--tRNA ligase -
OLR77_RS21780 (4455441) 4455441..4456898 - 1458 WP_282983371.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T262655 WP_001173343.1 NZ_CP110014:4453395-4453568 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT262655 WP_000398619.1 NZ_CP110014:4453071-4453367 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References