262649

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2868236..2868903 Replicon chromosome
Accession NZ_CP110014
Organism Escherichia coli strain HE_100-10

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag OLR77_RS14180 Protein ID WP_001094400.1
Coordinates 2868574..2868903 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag OLR77_RS14175 Protein ID WP_000072690.1
Coordinates 2868236..2868553 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR77_RS14140 (2863288) 2863288..2864297 - 1010 Protein_2765 arsenic transporter -
OLR77_RS14145 (2864439) 2864439..2866142 + 1704 WP_000896263.1 protein YfjW -
OLR77_RS14150 (2866753) 2866753..2866937 + 185 Protein_2767 DUF905 family protein -
OLR77_RS14155 (2866905) 2866905..2867027 - 123 WP_001407482.1 hypothetical protein -
OLR77_RS14160 (2867040) 2867040..2867498 + 459 WP_000211841.1 antirestriction protein -
OLR77_RS14165 (2867507) 2867507..2867989 + 483 WP_001407480.1 RadC family protein -
OLR77_RS14170 (2867998) 2867998..2868198 + 201 WP_001395452.1 DUF987 domain-containing protein -
OLR77_RS14175 (2868236) 2868236..2868553 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OLR77_RS14180 (2868574) 2868574..2868903 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
OLR77_RS14185 (2869267) 2869267..2873847 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T262649 WP_001094400.1 NZ_CP110014:2868574-2868903 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT262649 WP_000072690.1 NZ_CP110014:2868236-2868553 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References