Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
| Location | 2857039..2858476 | Replicon | chromosome |
| Accession | NZ_CP110014 | ||
| Organism | Escherichia coli strain HE_100-10 | ||
Toxin (Protein)
| Gene name | rnlA | Uniprot ID | P52129 |
| Locus tag | OLR77_RS14095 | Protein ID | WP_000155570.1 |
| Coordinates | 2857039..2858112 (+) | Length | 358 a.a. |
Antitoxin (Protein)
| Gene name | rnlB | Uniprot ID | P52130 |
| Locus tag | OLR77_RS14100 | Protein ID | WP_000461704.1 |
| Coordinates | 2858105..2858476 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OLR77_RS14080 (2852478) | 2852478..2854661 | - | 2184 | WP_282983212.1 | helicase-related protein | - |
| OLR77_RS14085 (2854658) | 2854658..2856274 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
| OLR77_RS14090 (2856634) | 2856634..2856897 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
| OLR77_RS14095 (2857039) | 2857039..2858112 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
| OLR77_RS14100 (2858105) | 2858105..2858476 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
| OLR77_RS14105 (2858831) | 2858831..2859694 | + | 864 | WP_000787597.1 | GTPase family protein | - |
| OLR77_RS14110 (2859786) | 2859786..2860607 | + | 822 | WP_000197391.1 | DUF932 domain-containing protein | - |
| OLR77_RS14115 (2860824) | 2860824..2861525 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
| OLR77_RS14120 (2861566) | 2861566..2861802 | + | 237 | WP_001144029.1 | protein YpjK | - |
| OLR77_RS14125 (2861802) | 2861802..2862245 | + | 444 | WP_000824222.1 | lipoprotein YfjS | - |
| OLR77_RS14130 (2862269) | 2862269..2862736 | + | 468 | WP_000702495.1 | protein YfjT | - |
| OLR77_RS14135 (2863123) | 2863123..2863275 | - | 153 | Protein_2764 | arsenate reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T262648 WP_000155570.1 NZ_CP110014:2857039-2858112 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT262648 WP_000461704.1 NZ_CP110014:2858105-2858476 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|