Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 439..1019 Replicon plasmid pKP424-7
Accession NZ_CP109989
Organism Klebsiella pneumoniae strain KP424

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag OJ961_RS29610 Protein ID WP_071177730.1
Coordinates 705..1019 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag OJ961_RS29605 Protein ID WP_000093040.1
Coordinates 439..717 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ961_RS29605 (OJ961_29610) 439..717 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
OJ961_RS29610 (OJ961_29615) 705..1019 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OJ961_RS29615 (OJ961_29620) 1183..1611 + 429 WP_001140599.1 hypothetical protein -
OJ961_RS29620 (OJ961_29625) 1637..1816 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
OJ961_RS29625 (OJ961_29630) 1843..2373 - 531 WP_071177729.1 hypothetical protein -
OJ961_RS29630 (OJ961_29635) 2380..3111 - 732 WP_071177728.1 MobC family replication-relaxation protein -
OJ961_RS29635 (OJ961_29640) 3111..5075 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T262628 WP_071177730.1 NZ_CP109989:705-1019 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT262628 WP_000093040.1 NZ_CP109989:439-717 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References