Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 19167..19702 Replicon plasmid pKP424-5
Accession NZ_CP109987
Organism Klebsiella pneumoniae strain KP424

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag OJ961_RS29195 Protein ID WP_016531292.1
Coordinates 19167..19454 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837JUA1
Locus tag OJ961_RS29200 Protein ID WP_023317799.1
Coordinates 19451..19702 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ961_RS29175 (OJ961_29180) 14724..15479 + 756 WP_001568031.1 replication initiation protein RepE -
OJ961_RS29180 (OJ961_29185) 16296..16826 + 531 WP_023317796.1 hypothetical protein -
OJ961_RS29185 (OJ961_29190) 17080..17367 - 288 WP_016529486.1 hypothetical protein -
OJ961_RS29190 (OJ961_29195) 17457..18119 - 663 WP_023317797.1 division plane positioning ATPase MipZ -
OJ961_RS29195 (OJ961_29200) 19167..19454 - 288 WP_016531292.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OJ961_RS29200 (OJ961_29205) 19451..19702 - 252 WP_023317799.1 hypothetical protein Antitoxin
OJ961_RS29205 (OJ961_29210) 19798..21066 - 1269 WP_023317800.1 Y-family DNA polymerase -
OJ961_RS29210 (OJ961_29215) 21066..21497 - 432 WP_023317801.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
OJ961_RS29215 (OJ961_29220) 21903..23390 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
OJ961_RS29220 (OJ961_29225) 23639..24610 + 972 WP_004152353.1 plasmid segregation protein ParM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81442 81442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11120.16 Da        Isoelectric Point: 10.4373

>T262626 WP_016531292.1 NZ_CP109987:c19454-19167 [Klebsiella pneumoniae]
MTYTVKFREDALKEWNKLDKTIQQQFAKKLKKCCENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDNQLIIAIVAVGK
RERSDVYTLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9239.60 Da        Isoelectric Point: 4.2108

>AT262626 WP_023317799.1 NZ_CP109987:c19702-19451 [Klebsiella pneumoniae]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELIKLVAERSNQPLFDVDLD
KYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837JUA1

References