Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1904..2481 Replicon plasmid pKP424-5
Accession NZ_CP109987
Organism Klebsiella pneumoniae strain KP424

Toxin (Protein)


Gene name mazF Uniprot ID A0A7G3NNX6
Locus tag OJ961_RS29075 Protein ID WP_059065587.1
Coordinates 2149..2481 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7G3NP82
Locus tag OJ961_RS29070 Protein ID WP_032454911.1
Coordinates 1904..2149 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ961_RS29070 (OJ961_29075) 1904..2149 + 246 WP_032454911.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
OJ961_RS29075 (OJ961_29080) 2149..2481 + 333 WP_059065587.1 endoribonuclease MazF Toxin
OJ961_RS29080 (OJ961_29085) 2741..3064 + 324 WP_021312689.1 hypothetical protein -
OJ961_RS29085 (OJ961_29090) 3315..4019 - 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
OJ961_RS29090 (OJ961_29095) 4179..5525 - 1347 WP_188201154.1 ISNCY family transposase -
OJ961_RS29095 (OJ961_29100) 5738..5992 - 255 WP_065810046.1 hypothetical protein -
OJ961_RS29100 (OJ961_29105) 6068..6325 - 258 WP_047665813.1 hypothetical protein -
OJ961_RS29105 (OJ961_29110) 6374..6577 - 204 WP_004152106.1 HHA domain-containing protein -
OJ961_RS29110 (OJ961_29115) 6611..6979 - 369 WP_122462932.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81442 81442
- flank IS/Tn - - 4179..5537 1358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11991.87 Da        Isoelectric Point: 7.7494

>T262625 WP_059065587.1 NZ_CP109987:2149-2481 [Klebsiella pneumoniae]
MVSRFVPDAGDLIWINFDPVEGHEQGGHRPAVVLSPFAYNNKTGLLLCVPCTTKVKGYPFEVELPGERDGVALADQITCV
DWRARKVEKKGKVATGELSEIRAKAKALIG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8881.21 Da        Isoelectric Point: 5.7996

>AT262625 WP_032454911.1 NZ_CP109987:1904-2149 [Klebsiella pneumoniae]
MSQATFKKWGNQAGIRFPAAVMKAAALNVDDTVDIEVQEGRIVLIPTKEKTYSLDALLSGITEENMHNKADFGKPTGKEM
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G3NNX6

Antitoxin

Source ID Structure
AlphaFold DB A0A7G3NP82

References