Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 118065..118735 | Replicon | plasmid pKP424-2 |
Accession | NZ_CP109984 | ||
Organism | Klebsiella pneumoniae strain KP424 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | Q6U619 |
Locus tag | OJ961_RS27030 | Protein ID | WP_004213072.1 |
Coordinates | 118065..118508 (-) | Length | 148 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | Q6U620 |
Locus tag | OJ961_RS27035 | Protein ID | WP_004213073.1 |
Coordinates | 118505..118735 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OJ961_RS26995 (OJ961_27000) | 113476..113751 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
OJ961_RS27000 (OJ961_27005) | 113814..114305 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
OJ961_RS27005 (OJ961_27010) | 114354..115274 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
OJ961_RS27010 (OJ961_27015) | 115365..115768 | + | 404 | Protein_127 | GAF domain-containing protein | - |
OJ961_RS27015 (OJ961_27020) | 116286..116921 | - | 636 | WP_165475474.1 | mucoid phenotype regulator RmpA2 | - |
OJ961_RS27020 (OJ961_27025) | 117338..117642 | + | 305 | Protein_129 | transposase | - |
OJ961_RS27025 (OJ961_27030) | 117665..117916 | - | 252 | WP_186987481.1 | hypothetical protein | - |
OJ961_RS27030 (OJ961_27035) | 118065..118508 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
OJ961_RS27035 (OJ961_27040) | 118505..118735 | - | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
OJ961_RS27040 (OJ961_27045) | 119343..120476 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
OJ961_RS27045 (OJ961_27050) | 120492..120785 | + | 294 | WP_004213076.1 | hypothetical protein | - |
OJ961_RS27050 (OJ961_27055) | 120775..120981 | - | 207 | WP_004213077.1 | hypothetical protein | - |
OJ961_RS27055 (OJ961_27060) | 121333..121623 | + | 291 | WP_004213078.1 | hypothetical protein | - |
OJ961_RS27060 (OJ961_27065) | 121613..122512 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 | iucA / iucB / iucC / iucD / iutA / rmpA | 1..293179 | 293179 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T262620 WP_004213072.1 NZ_CP109984:c118508-118065 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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