262619

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 41197..41723 Replicon plasmid pKP424-2
Accession NZ_CP109984
Organism Klebsiella pneumoniae strain KP424

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag OJ961_RS26635 Protein ID WP_000323025.1
Coordinates 41436..41723 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag OJ961_RS26630 Protein ID WP_000534858.1
Coordinates 41197..41436 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ961_RS26600 (OJ961_26605) 37582..37893 + 312 Protein_45 IS110 family transposase -
OJ961_RS26605 (OJ961_26610) 37903..38211 - 309 Protein_46 integrase core domain-containing protein -
OJ961_RS26610 (OJ961_26615) 38228..39304 - 1077 WP_000227969.1 IS110 family transposase -
OJ961_RS26615 (OJ961_26620) 39586..40445 - 860 Protein_48 IS3-like element ISEc52 family transposase -
OJ961_RS26620 (OJ961_26625) 40518..40934 + 417 Protein_49 cation-efflux pump -
OJ961_RS26625 (OJ961_26630) 41068..41172 - 105 Protein_50 hypothetical protein -
OJ961_RS26630 (OJ961_26635) 41197..41436 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
OJ961_RS26635 (OJ961_26640) 41436..41723 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OJ961_RS26640 (OJ961_26645) 41795..41953 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
OJ961_RS26645 (OJ961_26650) 42556..43530 + 975 WP_004181899.1 hypothetical protein -
OJ961_RS26650 (OJ961_26655) 43728..44105 - 378 WP_004181901.1 hypothetical protein -
OJ961_RS26655 (OJ961_26660) 44795..45862 + 1068 WP_004181903.1 hypothetical protein -
OJ961_RS26660 (OJ961_26665) 46018..46365 + 348 WP_004181904.1 hypothetical protein -
OJ961_RS26665 (OJ961_26670) 46444..46677 + 234 WP_004181905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 iucA / iucB / iucC / iucD / iutA / rmpA 1..293179 293179


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T262619 WP_000323025.1 NZ_CP109984:41436-41723 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT262619 WP_000534858.1 NZ_CP109984:41197-41436 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References