Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 41197..41723 Replicon plasmid pKP424-2
Accession NZ_CP109984
Organism Klebsiella pneumoniae strain KP424

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag OJ961_RS26635 Protein ID WP_000323025.1
Coordinates 41436..41723 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag OJ961_RS26630 Protein ID WP_000534858.1
Coordinates 41197..41436 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ961_RS26600 (OJ961_26605) 37582..37893 + 312 Protein_45 IS110 family transposase -
OJ961_RS26605 (OJ961_26610) 37903..38211 - 309 Protein_46 integrase core domain-containing protein -
OJ961_RS26610 (OJ961_26615) 38228..39304 - 1077 WP_000227969.1 IS110 family transposase -
OJ961_RS26615 (OJ961_26620) 39586..40445 - 860 Protein_48 IS3-like element ISEc52 family transposase -
OJ961_RS26620 (OJ961_26625) 40518..40934 + 417 Protein_49 cation-efflux pump -
OJ961_RS26625 (OJ961_26630) 41068..41172 - 105 Protein_50 hypothetical protein -
OJ961_RS26630 (OJ961_26635) 41197..41436 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
OJ961_RS26635 (OJ961_26640) 41436..41723 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OJ961_RS26640 (OJ961_26645) 41795..41953 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
OJ961_RS26645 (OJ961_26650) 42556..43530 + 975 WP_004181899.1 hypothetical protein -
OJ961_RS26650 (OJ961_26655) 43728..44105 - 378 WP_004181901.1 hypothetical protein -
OJ961_RS26655 (OJ961_26660) 44795..45862 + 1068 WP_004181903.1 hypothetical protein -
OJ961_RS26660 (OJ961_26665) 46018..46365 + 348 WP_004181904.1 hypothetical protein -
OJ961_RS26665 (OJ961_26670) 46444..46677 + 234 WP_004181905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 iucA / iucB / iucC / iucD / iutA / rmpA 1..293179 293179


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T262619 WP_000323025.1 NZ_CP109984:41436-41723 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT262619 WP_000534858.1 NZ_CP109984:41197-41436 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References