Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 32641..33551 | Replicon | plasmid pKP424-2 |
| Accession | NZ_CP109984 | ||
| Organism | Klebsiella pneumoniae strain KP424 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | OJ961_RS26580 | Protein ID | WP_004026354.1 |
| Coordinates | 33081..33551 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | OJ961_RS26575 | Protein ID | WP_004181895.1 |
| Coordinates | 32641..33084 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OJ961_RS26560 (OJ961_26565) | 29274..30761 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| OJ961_RS26565 (OJ961_26570) | 30847..31269 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| OJ961_RS26570 (OJ961_26575) | 31269..32540 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| OJ961_RS26575 (OJ961_26580) | 32641..33084 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| OJ961_RS26580 (OJ961_26585) | 33081..33551 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| OJ961_RS26585 (OJ961_26590) | 33661..33921 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| OJ961_RS26590 (OJ961_26595) | 34492..35673 | - | 1182 | WP_078207741.1 | IS481 family transposase | - |
| OJ961_RS26595 (OJ961_26600) | 35821..37161 | + | 1341 | WP_000589001.1 | ISNCY family transposase | - |
| OJ961_RS26600 (OJ961_26605) | 37582..37893 | + | 312 | Protein_45 | IS110 family transposase | - |
| OJ961_RS26605 (OJ961_26610) | 37903..38211 | - | 309 | Protein_46 | integrase core domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 | iucA / iucB / iucC / iucD / iutA / rmpA | 1..293179 | 293179 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T262618 WP_004026354.1 NZ_CP109984:33081-33551 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT262618 WP_004181895.1 NZ_CP109984:32641-33084 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |