262617

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5382853..5383478 Replicon chromosome
Accession NZ_CP109983
Organism Klebsiella pneumoniae strain KP424

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OJ961_RS26010 Protein ID WP_002882817.1
Coordinates 5382853..5383236 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OJ961_RS26015 Protein ID WP_004150355.1
Coordinates 5383236..5383478 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ961_RS25995 (5380219) 5380219..5381121 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OJ961_RS26000 (5381118) 5381118..5381753 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OJ961_RS26005 (5381750) 5381750..5382679 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OJ961_RS26010 (5382853) 5382853..5383236 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OJ961_RS26015 (5383236) 5383236..5383478 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OJ961_RS26020 (5383683) 5383683..5384600 + 918 WP_004181612.1 alpha/beta hydrolase -
OJ961_RS26025 (5384614) 5384614..5385555 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OJ961_RS26030 (5385600) 5385600..5386037 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OJ961_RS26035 (5386034) 5386034..5386894 - 861 WP_004146232.1 virulence factor BrkB family protein -
OJ961_RS26040 (5386888) 5386888..5387487 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T262617 WP_002882817.1 NZ_CP109983:c5383236-5382853 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT262617 WP_004150355.1 NZ_CP109983:c5383478-5383236 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References