Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4912902..4913418 Replicon chromosome
Accession NZ_CP109983
Organism Klebsiella pneumoniae strain KP424

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OJ961_RS23770 Protein ID WP_004178374.1
Coordinates 4912902..4913186 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OJ961_RS23775 Protein ID WP_002886901.1
Coordinates 4913176..4913418 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ961_RS23745 (4908386) 4908386..4908649 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
OJ961_RS23750 (4908779) 4908779..4908952 + 174 WP_032408826.1 hypothetical protein -
OJ961_RS23755 (4908955) 4908955..4909698 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OJ961_RS23760 (4910055) 4910055..4912193 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OJ961_RS23765 (4912434) 4912434..4912898 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OJ961_RS23770 (4912902) 4912902..4913186 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OJ961_RS23775 (4913176) 4913176..4913418 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OJ961_RS23780 (4913496) 4913496..4915406 - 1911 WP_004178373.1 PRD domain-containing protein -
OJ961_RS23785 (4915429) 4915429..4916583 - 1155 WP_004178372.1 lactonase family protein -
OJ961_RS23790 (4916650) 4916650..4917390 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T262615 WP_004178374.1 NZ_CP109983:c4913186-4912902 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT262615 WP_002886901.1 NZ_CP109983:c4913418-4913176 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References