Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2820646..2822234 Replicon chromosome
Accession NZ_CP109983
Organism Klebsiella pneumoniae strain KP424

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OJ961_RS13675 Protein ID WP_004179815.1
Coordinates 2820646..2821968 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OJ961_RS13680 Protein ID WP_004176198.1
Coordinates 2821968..2822234 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ961_RS13660 (2815703) 2815703..2818203 + 2501 Protein_2678 fimbrial biogenesis outer membrane usher protein -
OJ961_RS13665 (2818191) 2818191..2819195 + 1005 WP_004179822.1 fimbrial protein -
OJ961_RS13670 (2819337) 2819337..2820629 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OJ961_RS13675 (2820646) 2820646..2821968 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
OJ961_RS13680 (2821968) 2821968..2822234 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OJ961_RS13685 (2822500) 2822500..2822826 - 327 WP_002904788.1 hydroxyisourate hydrolase -
OJ961_RS13690 (2822823) 2822823..2823323 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OJ961_RS13695 (2823301) 2823301..2824680 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
OJ961_RS13700 (2825026) 2825026..2826180 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OJ961_RS13705 (2826161) 2826161..2827084 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2614778..2857069 242291


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T262610 WP_004179815.1 NZ_CP109983:c2821968-2820646 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT262610 WP_004176198.1 NZ_CP109983:c2822234-2821968 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References