Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2820646..2822234 | Replicon | chromosome |
Accession | NZ_CP109983 | ||
Organism | Klebsiella pneumoniae strain KP424 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | OJ961_RS13675 | Protein ID | WP_004179815.1 |
Coordinates | 2820646..2821968 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | OJ961_RS13680 | Protein ID | WP_004176198.1 |
Coordinates | 2821968..2822234 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OJ961_RS13660 (2815703) | 2815703..2818203 | + | 2501 | Protein_2678 | fimbrial biogenesis outer membrane usher protein | - |
OJ961_RS13665 (2818191) | 2818191..2819195 | + | 1005 | WP_004179822.1 | fimbrial protein | - |
OJ961_RS13670 (2819337) | 2819337..2820629 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
OJ961_RS13675 (2820646) | 2820646..2821968 | - | 1323 | WP_004179815.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
OJ961_RS13680 (2821968) | 2821968..2822234 | - | 267 | WP_004176198.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
OJ961_RS13685 (2822500) | 2822500..2822826 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
OJ961_RS13690 (2822823) | 2822823..2823323 | - | 501 | WP_004179811.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
OJ961_RS13695 (2823301) | 2823301..2824680 | - | 1380 | WP_004179808.1 | nucleobase:cation symporter-2 family protein | - |
OJ961_RS13700 (2825026) | 2825026..2826180 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
OJ961_RS13705 (2826161) | 2826161..2827084 | - | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | mgtC / iroE | 2614778..2857069 | 242291 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49152.42 Da Isoelectric Point: 7.2850
>T262610 WP_004179815.1 NZ_CP109983:c2821968-2820646 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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