Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 953273..953930 Replicon chromosome
Accession NZ_CP109983
Organism Klebsiella pneumoniae strain KP424

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OJ961_RS04705 Protein ID WP_002916310.1
Coordinates 953520..953930 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OJ961_RS04700 Protein ID WP_002916312.1
Coordinates 953273..953539 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ961_RS04675 (948429) 948429..949862 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
OJ961_RS04680 (949981) 949981..950709 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OJ961_RS04685 (950759) 950759..951070 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
OJ961_RS04690 (951234) 951234..951893 + 660 WP_002916317.1 hemolysin III family protein -
OJ961_RS04695 (952044) 952044..953027 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
OJ961_RS04700 (953273) 953273..953539 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OJ961_RS04705 (953520) 953520..953930 + 411 WP_002916310.1 protein YgfX Toxin
OJ961_RS04710 (953937) 953937..954458 - 522 WP_004144730.1 flavodoxin FldB -
OJ961_RS04715 (954559) 954559..955455 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OJ961_RS04720 (955478) 955478..956191 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OJ961_RS04725 (956197) 956197..957930 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T262605 WP_002916310.1 NZ_CP109983:953520-953930 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT262605 WP_002916312.1 NZ_CP109983:953273-953539 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References