Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 712878..713557 Replicon chromosome
Accession NZ_CP109983
Organism Klebsiella pneumoniae strain KP424

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag OJ961_RS03535 Protein ID WP_020324801.1
Coordinates 713216..713557 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag OJ961_RS03530 Protein ID WP_020324792.1
Coordinates 712878..713195 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ961_RS03505 (708092) 708092..711244 + 3153 WP_022631414.1 AIDA repeat-containing protein -
OJ961_RS03510 (711337) 711337..711576 + 240 WP_020324820.1 DUF905 domain-containing protein -
OJ961_RS03515 (711679) 711679..712137 + 459 WP_020324813.1 antirestriction protein -
OJ961_RS03520 (712153) 712153..712629 + 477 WP_020324797.1 RadC family protein -
OJ961_RS03525 (712638) 712638..712865 + 228 WP_020324796.1 DUF987 domain-containing protein -
OJ961_RS03530 (712878) 712878..713195 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OJ961_RS03535 (713216) 713216..713557 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
OJ961_RS03540 (713673) 713673..714506 + 834 WP_020324805.1 DUF4942 domain-containing protein -
OJ961_RS03550 (714809) 714809..715315 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
OJ961_RS03555 (715415) 715415..717256 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA / fimI / fimC / fimD / fimD / fimF / fimG 666531..714506 47975


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T262604 WP_020324801.1 NZ_CP109983:713216-713557 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT262604 WP_020324792.1 NZ_CP109983:712878-713195 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References