262591

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5361845..5362470 Replicon chromosome
Accession NZ_CP109973
Organism Klebsiella pneumoniae strain 857

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OI501_RS26475 Protein ID WP_002882817.1
Coordinates 5361845..5362228 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OI501_RS26480 Protein ID WP_004150355.1
Coordinates 5362228..5362470 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI501_RS26460 (OI501_26465) 5359211..5360113 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OI501_RS26465 (OI501_26470) 5360110..5360745 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OI501_RS26470 (OI501_26475) 5360742..5361671 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OI501_RS26475 (OI501_26480) 5361845..5362228 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OI501_RS26480 (OI501_26485) 5362228..5362470 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OI501_RS26485 (OI501_26490) 5362675..5363592 + 918 WP_002882812.1 alpha/beta hydrolase -
OI501_RS26490 (OI501_26495) 5363606..5364547 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OI501_RS26495 (OI501_26500) 5364592..5365029 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OI501_RS26500 (OI501_26505) 5365026..5365886 - 861 WP_002882807.1 virulence factor BrkB family protein -
OI501_RS26505 (OI501_26510) 5365880..5366479 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T262591 WP_002882817.1 NZ_CP109973:c5362228-5361845 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT262591 WP_004150355.1 NZ_CP109973:c5362470-5362228 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References