262588

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4775811..4776621 Replicon chromosome
Accession NZ_CP109973
Organism Klebsiella pneumoniae strain 857

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag OI501_RS23655 Protein ID WP_002887280.1
Coordinates 4775811..4776344 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag OI501_RS23660 Protein ID WP_002887278.1
Coordinates 4776355..4776621 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI501_RS23650 (OI501_23655) 4774642..4775763 + 1122 WP_002887282.1 cupin domain-containing protein -
OI501_RS23655 (OI501_23660) 4775811..4776344 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
OI501_RS23660 (OI501_23665) 4776355..4776621 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
OI501_RS23665 (OI501_23670) 4776724..4778157 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
OI501_RS23670 (OI501_23675) 4778147..4778830 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
OI501_RS23675 (OI501_23680) 4779002..4780387 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
OI501_RS23680 (OI501_23685) 4780405..4780749 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T262588 WP_002887280.1 NZ_CP109973:c4776344-4775811 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT262588 WP_002887278.1 NZ_CP109973:c4776621-4776355 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References